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Diuretic and corticosteroid combination
May Be Prescribed by Vets for:
Non-specific swelling or edema
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Trichlormethiazide and dexamethasone (Tri Dex) combination is an oral product that was licensed and marketed under the brand name of Naquasone® as a treatment for udder edema in the cow. Many veterinarians use this drug combination in horses to reduce mild swellings, particularly of the legs. Trichlormethiazide is a diuretic that works at the level of the proximal tubules of the kidneys to decrease the reabsorption of sodium. It has little effect on potassium excretion. Dexamethasone is a corticosteroid. A full discussion of the anti-inflammatory effects and side effects associated with dexamethasone are discussed in thedexamethasone monograph. One of the benefits of using a combination product is that each component works by a different mechanism. This may allow a smaller dose of the individual drugs than might be used if the drug were given individually.
Tri Dex has been used by equine practitioners to treat mild swellings of the distal limbs. Because of the relatively small dose of the individual drugs, it generally is thought to be a safe product for bumps, bruises, non-specific edema, or stocking up. It sometimes is used in conjunction with antibiotics in leg wounds where there is both a bacterial component, and inflammation or contusion. Tri Dex does not cure the underlying cause of the swelling or edema and should not be used without appropriate diagnostic evaluation.
Trichlormethiazide and Dexamethasone Side Effects
Tri Dex should not be used at the same time as other corticosteroids or diuretics.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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