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Steroid hormone combination
May Be Prescribed by Vets for:
Regulation of estrus, synchronization of estrus, delay of post foaling estrus, pregnancy maintenance.
Estradiol Combination is commercially available as
Synovex® C (Prog 100mg, Estradiol 10mg) & Synovex S
(Prog 200mg, Estradiol 20mg) implant
The most commonly followed protocol for estrus regulation or synchronization is once a day IM injection of 150mg of progesterone combined with 10 mg of estradiol for 10 days. On the tenth day prostaglandin is given in addition to the last P and E shot. Different studies vary in their results, but about 80% of mares given this treatment regimen will ovulate between eight and 10 days after the last injection. P and E also is used for pregnancy maintenance and is accepted as safe in the pregnant and lactating mare. P and E may be used to delay the first postpartum estrus. Pony breeds are similar to horses in their response to P and E.
The most-common side effect is injection-site reaction. These reactions usually respond to hot compresses and NSAIDs.
Compounds containing progesterone should not be used in mares with chronic uterine infections.
Rifampin may decrease progesterone's activity. It is difficult to envision an occasion when a broodmare would be on both rifampin and P and E.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.