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Carbonic anhydrase inhibitor
Dogs (to a lesser degree, cats)
May Be Prescribed by Vets for:
Search for Available Dosage Forms
Methazolamide is a carbonic anhydrase inhibitor (CAI) that is used in the medical management of both primary and secondary glaucoma. Carbonic anhydrase is an enzyme that is necessary for the production of aqueous humor. Methazolamide inhibits this enzyme, resulting in a decrease of the production of aqueous humor, and lower intraocular pressure. Other effects of CAI’s include increased renal excretion of sodium, potassium, and bicarbonate. Animals that are receiving CAI’s will have increased urinary pH, increased urine volume, and a tendency towards metabolic acidosis.
Oral methazolamide is used in the acute and long-term management of both primary and secondary glaucoma in dogs. It is less commonly used in cats as they are more likely to have unacceptable side-effects with the CAI drugs. Methazolamide is absorbed from the digestive tract with significantly increased levels present at three to six hours post-administration. Research in normal dogs indicates that there is some diurnal variation in intraocular pressure (IOP). The morning IOP is generally higher than the evening pressure. Some animals can be managed with once a day medication and others will need twice a day treatment. Methazolamide is frequently used with other drugs such as prostaglandin analogues, topical miotics, and beta blockers.
Methazolamide may also be used as a part of the medical management of anterior uveitis in dogs if intraocular pressure is elevated in the affected eye.
There is no specific information regarding overdose of methazolamide. Overdose would potentially increase the likelihood and severity of the previously mentioned side effects.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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