Ordering patient medications is easy. With an online account, access our extensive formulary or over 20,000 unique items - 24 hours a day, 7 days a week.
Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program.
Nonsteroidal anti-inflammatory drug (NSAID)
May Be Prescribed by Vets for:
Chronic and acute inflammatory diseases of the musculoskeletal system.
Search for Available Dosage Forms
Meclofenamate is chemically the same compound as meclofenamic acid, which was marketed under the trade name of Arquel®. It is an anthranilic acid derivative with similar pharmacologic activity as aspirin. Like other NSAIDs, meclofenamate is a potent inhibitor of the enzyme cyclooxygenase. It is well-absorbed orally with detectable levels being reached within 30 minutes and peak levels at one to four hours post administration. Interestingly, full clinical response is thought to take 36 - 96 hours. Meclofenamate is highly protein-bound; it is metabolized by the liver and excreted in the urine and feces. Although meclofenamate has a transient effect on platelet aggregation, it does not affect bleeding times. Meclofenamate was at one time used as an NSAID in dogs, but now there are other canine-specific NSAIDs that are considered safer.
Meclofenamate is used to treat acute and chronic inflammation of the musculoskeletal system, including soft-tissue injury, bone and joint pathology, and laminitis. It is thought to be particularly useful in chronic problems of the hoof, including navicular syndrome and laminitis.
Because meclofenamate has a slow onset of full clinical action, other NSAIDs are used more commonly to treat colic or to reduce fevers.
Recent research has investigated the use of meclofenamate in embryo transfer programs to improve conception rates when the synchronization of the recipient mares is not within the ideal window. Normally, embryo transfer in the horse is most successful when the recipient mare ovulates one to two days after the donor mare. In a study done at the University of Cambridge, 81% of the recipient mares treated with meclofenamate became pregnant even when they had ovulated as early as two to three days prior to the donor mare.
Meclofenamate is permitted under the therapeutic substance rules of the USEF. Further information regarding NSAID use at USEF competitions may be found on its Web site, www.USEF.org.
The most-common side effects are those seen with all NSAIDs: decreased packed-cell volume due to bleeding, ulceration of the mouth and GI tract, colic, and diarrhea.
Meclofenamate should be used with additional caution with other drugs that may cause GI ulceration, including corticosteroids or other NSAIDs. In particular, combination with aspirin may increase blood loss due to GI side-effects.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
Some states restrict the information we may provide about controlled substances. Please select your state below.
405 HERON DRIVE SUITE 200 • SWEDESBORO, NJ 08085-1749 | © 2004-2017 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED.
This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.