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Aminoglycoside antibiotic and anti-diarrheal combination
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Kanamycin with bismuth subcarbonate and activated attapulgite is a combination antibiotic and anti-diarrheal. This drug combination is used to treat diarrhea of bacterial origin. There is a similar FDA approved product that has these three ingredients with the addition of pectin.
Kanamycin is an aminoglycoside antibiotic. Aminoglycosides are bactericidal and are very poorly absorbed through the GI tract. Oral administration of kanamycin allows for local treatment within the GI tract of susceptible enteric bacteria, including Salmonella, Shigella, Alcaligenes faecalis, E. coli, Proteus, and Staph aureus. When aminoglycoside antibiotics are used to treat a systemic infection, they must be used parenterally.
Bismuth subcarbonate is a traditional mucosal protectant of the GI tract. It is not thought to be absorbed in any significant quantity. Activated attapulgite is a clay mineral that is also not absorbed from the GI tract. Activated attapulgite binds bacteria and bacterial toxins. It also decreases the number of bowel movements, relieves cramping, and improves fecal consistency.
Kanamycin with bismuth subcarbonate and activated attapulgite is an oral drug combination that is used to treat bacterial enteritis in dogs. These drugs are locally effective within the GI tract. Aminoglycoside antibiotics are generally ineffective against anaerobic bacteria, protozoa, and viruses.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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