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Griseofulvin is an antifungal agent which, when taken orally, is active against the superficial fungi that cause ringworm of the skin, hair and claws. Griseofulvin has activity against Trichophyton, Microsporum and Epidermophyton. It has no antibacterial activity and is not effective against other fungi. It is approved for use in dogs, cats and horses. Adverse effects include anemia, anorexia, depression, vomiting and diarrhea. Safety in pregnant animals has not been established. Griseofulvin should be given with food to enhance absorption. Griseofulvin enhances cytochrome P-450 enzymes and may cause an increased metabolism and clearance of concurrently administered drugs. The FDA label use of griseofulvin is to treat ringworm infections caused by trichophyton equinum and microsporum gypseum. The usual dose for a 1,000 pound horse is 2.5 grams once daily by mouth for a minimum of 10 days.
In my practice, most of the griseofulvin use is off-label. Dr. Edwin Churchill observed in a clinical setting that griseofulvin is a useful adjunct therapy to antibiotics when treating lower airway disease and the accompanying mucous. A single bolus ten-day dose of 25 grams is administered by stomach tube or paste when the antibiotics are initiated.
To facilitate the suspension and administration of the griseofulvin powder, place the griseofulvin powder in a pitcher. Add five to six capfuls of docusate sodium liquid 50mg/5ml and mix with the powder to make a paste before adding water. The docusate sodium is a surfactant and helps to wet the powders making mixing with water easier.
Dr. Roger Omwake graduated from Ohio State University in 1971 and is currently practicing at the Rosecroft Raceway in Fort Washington, Maryland. He has been in a standardbred racetrack practice since 1971.
Dr. Omwake is a member of the American Association of Equine Practitioners, The Ohio Veterinary Medical Association, and the American Veterinary Medical Association.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.