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Selective Serotonin Re-uptake Inhibitor (SSRI)
Dogs and cats
May Be Prescribed by Vets for:
Dogs:separation anxiety, inter-canine aggression, stereotypic behavior.Cats: anxiety, stereotypic behavior, inappropriate elimination.
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Fluoxetine is an SSRI. The originally marketed human drug is called Prozac®. Fluoxetine increases serotonin levels within the central nervous system by preventing the re-uptake of serotonin at the level of the presynaptic neuron. This allows serotonin to accumulate in the synaptic cleft and affect the post-synaptic neuron. Serotonin is the neurotransmitter responsible for facilitating social interactions, general awareness, coping mechanism, and adaptability. SSRI drugs commonly are prescribed for humans as a part of the treatment of depression, anxiety disorders, compulsive disorders, and difficulty managing aggression. Fluoxetine must be administered for four to eight weeks before the full effect on serotonin levels is realized.
Fluoxetine is well-absorbed orally. Although the bioavailability of transdermal fluoxetine is only about 10% of that of the oral medication, it may be an alternative when oral administration is not feasible or safe.
Fluoxetine is FDA-approved for use in separation anxiety in dogs. All other uses of fluoxetine in dogs and cats are extra-label but there is considerable literature and experience on the use of SSRI's for small-animal behavior problems. In addition to the use of medication, much of the behavior literature stresses the importance of behavior modification training, owner training, and addressing environmental issues as cornerstones of successful therapy.
Fluoxetine is useful to treat some but not all forms of aggression in dogs. It is used for inter-dog aggression in conjunction with behavioral training and neutering of the less dominant dog. Fluoxetine also is used to treat obsessive compulsive disorders in dogs. Specific phobias such as fear of storms usually are treated by benzodiazepines because of their episodic nature and the drug's rapid onset of action. There are instances when combining a SSRI and a benzodiazepine are warranted because of the need for a brief period of increased anxiolytic, such as the first half hour of separation for a dog with marked separation-anxiety.
Indoor cats appear to be susceptible to anxiety disorders due to their lack of social skills and the importance of territorial organization. Manifestations of anxiety in cats may include inappropriate elimination, aggression, obsessive compulsive behavior, hyperactivity, or hypervigilance. Fluoxetine may be helpful for cohabitation anxiety, closed surrounding anxiety, and territory related anxiety. Because of the high rate of recidivism in cats that urine spray, fluoxetine therapy may need to be continued for a month or two after the resolution of the spraying problem.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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