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Dogs, cats and horses
May Be Prescribed by Veterinarians for:
Doxycycline is commercially available as capsule/tablet
20mg, 50mg, 75mg, 100mg, 150mg, delayed release
capsule/tablet 40mg, 50mg, 75mg, 100mg, 120mg, 150mg,
200mg, reconstituted solution 100mg, reconstituted
suspension 25mg/5ml, oral syrup 50mg/5ml.
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Doxycycline is a semi-synthetic tetracycline antibiotic, derived from oxytetracycline. It may be used orally (dogs, cats and horses) or intravenously (dogs and cats). Tetracycline antibiotics are broad-spectrum and bacteriostatic. Their mechanism of action is through the inhibition of protein synthesis, and the alteration of cytoplasmic membrane permeability within the susceptible organism.
Doxycycline is more lipid-soluble than other tetracycline antibiotics and may reach higher levels in some of the difficult to penetrate areas, such as synovial fluid, central nervous system, prostate, and the eyes.
Tetracycline antibiotics, including doxycycline, are effective against a broad spectrum of gram-negative and gram-positive bacteria, and wide variety of other organisms including Rickettsia, Spirochetes, Mycoplasma, Leptospira, Anaplasma, and Chlamydia. In addition to its use as an antibiotic, doxycycline is used in low doses as an anti-inflammatory and adjunct treatment for arthritis and degenerative joint-disease in dogs and horses. This use is based on the inhibition of metallo-matrix proteinases.
Doxycycline is well-absorbed after oral administration and its absorption is minimally affected by the presence of food in the stomach. Doxycycline may be used in animals with decreased kidney function because it is eliminated primarily via the GI tract.
Doxycycline is used in dogs to treat susceptible bacterial infections and infections caused by Rickettsia, Canine ehrlichiosis (anaplasmosis), Toxoplasma, Borrelia burgdorferi (Lyme disease), Leptospirosis and Neorickettsia helminthoeca (salmon poisoning).
Doxycycline is used in cats to treat susceptible bacterial infections and infections caused by a number of other organisms including Bartonella, Hemoplasma, Chlamydia felis, Ehrlichia, Anaplasma, and Toxoplasma.
There is some interesting research regarding the use of doxycycline as a “pre-treatment” in animals with circulating microfilaria due to heartworm disease. The research indicates that the pathogenic microfilaria are generally infected with a symbiotic bacteria called Wolbachia, which is sensitive to doxycycline. Pre-treatment with doxycycline is postulated to adverse reactions to microfilaria death.
Doxycycline gel is used topically in the mouth of dogs and cats for periodontal disease. Local application in the sulcus provides higher concentrations of the drug than may be achieved with systemic antibiotics.
Doxycycline is used in horses to treat susceptible bacterial-infections and tick-borne diseases such as Ehrlichia, Anaplasma, and Borrelia burgdorferi (Lyme disease).
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the products shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular product. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration ("FDA"), nor has the FDA approved the products to diagnose, cure or prevent disease.
Wedgewood Pharmacy compounded veterinary preparations are not intended for use in food and food-producing animals.
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The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the medications shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular medication. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration ("FDA"), nor has the FDA approved the medications to diagnose, cure or prevent disease.
Medications compounded by Wedgewood Pharmacy are prepared at the direction of a veterinarian. Wedgewood Pharmacy compounded veterinary preparations are not intended for use in food and food-producing animals.
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