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Dogs, cats and horses
May Be Prescribed by Vets for:
Esophageal reflux or megaesophagus, anti-emetic, post-operative ileus, delayed gastric-emptying, megacolon.
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Cisapride activates acetylcholine release from the mesenteric plexus, which in turn stimulates GI smooth-muscle. Cisapride is a serotonergic agonist. Cisapride can show activity on the smooth muscle throughout the GI tract. Anatomic differences between species can affect clinical efficacy. For example, cisapride is not used generally to manage megaesophagus in dogs because they lack smooth muscle in the esophagus. Like cisapride, metoclopramide and domperidone also are drugs in the benzamide class. Cisapride does not increase gastric acid secretion.
Cisapride has been used widely to treat gastric-emptying disorders, intestinal transit and other motility disorders in both dogs and cats. It accelerates emptying the stomach and propulsion of food through the intestines by increasing peristalsis. Cisapride is used in cats to manage chronic constipation and megacolon.
Work in humans has shown that cisapride is better absorbed when given with food. In small-animal practice it usually is recommended that cisapride be given orally 15 minutes before feeding.
GI symptoms including abdominal pain and diarrhea are common.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the medications shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular medication. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration ("FDA"), nor has the FDA approved the medications to diagnose, cure or prevent disease.
Medications compounded by Wedgewood Pharmacy are prepared at the direction of a veterinarian. Wedgewood Pharmacy compounded veterinary preparations are not intended for use in food and food-producing animals.