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Dogs, cats and horses
May Be Prescribed by Vets for:
Esophageal reflux or megaesophagus, anti-emetic, post-operative ileus, delayed gastric-emptying, megacolon.
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Cisapride activates acetylcholine release from the mesenteric plexus, which in turn stimulates GI smooth-muscle. Cisapride is a serotonergic agonist. Cisapride can show activity on the smooth muscle throughout the GI tract. Anatomic differences between species can affect clinical efficacy. For example, cisapride is not used generally to manage megaesophagus in dogs because they lack smooth muscle in the esophagus. Like cisapride, metoclopramide and domperidone also are drugs in the benzamide class. Cisapride does not increase gastric acid secretion.
Cisapride has been used widely to treat gastric-emptying disorders, intestinal transit and other motility disorders in both dogs and cats. It accelerates emptying the stomach and propulsion of food through the intestines by increasing peristalsis. Cisapride is used in cats to manage chronic constipation and megacolon.
Work in humans has shown that cisapride is better absorbed when given with food. In small-animal practice it usually is recommended that cisapride be given orally 15 minutes before feeding.
GI symptoms including abdominal pain and diarrhea are common.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.