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Dogs, cats and horses
May Be Prescribed by Vets for:
Pemphigus, leukemia, lymphosarcoma, irritable- bowel syndrome, ovarian adenocarcinoma, glomerulonephritis, feline eosinophillic-granuloma complex, plasma-cell gingivitis and pharyngitis.
Chlorambucil is commercially available as Leukeran
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Chlorambucil is used in dogs to treat canine lymphoma, chronic lymphocytic leukemia, lymphoreticular neoplasms, macroglobinemia, polycythemia vera, and inflammatory bowel disease. It also may be used in combination with Prednisone when treating Pemphigus complex.
Chlorambucil is used in cats to treat lymphocytic leukemia, lymphocytic plasmacytic enteritis, Pemphigus, inflammatory bowel disease, and feline eosinophillic granuloma complex. Chlorambucil is considered safer than Azathioprine for use in cats.
Chlorambucil has been used within a multiple-drug protocol to treat lymphoma in horses.
Side effects primarily are gastrointestinal distress (including vomiting and diarrhea) and bone marrow suppression. Alopecia, particularly in Poodles and Kerry Blues, has been reported. Seizures are a rarer side effect.
Chlorambucil should be used with caution with other myelosuppressive or immunosuppressive drugs due to additive bone marrow suppression or increased risk of infection.
Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.
She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.
Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.
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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Wedgewood Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.