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Top 10 human medications toxic to dogs and cats

Veterinary: Prescribe Now
Pet Owners: Pick Up and Fill a New Prescription
Tuesday, October 11, 2011

Pet Poison Helpline Pet owners who are serious about pet-proofing their home should start with their own medicine cabinet. Pet Poison Helpline is a 24-hour service available throughout North America for pet owners and veterinary professionals who require assistance treating a potentially poisoned pet. Nearly 50% of the calls received by Pet Poison Helpline involve human medications – both over-the-counter and prescription. Whether Fido accidentally chewed into a pill bottle or a well-intentioned pet owner accidently switched medication (giving their pet a human medication), pet poisonings due to medication are common and can be very serious.

Below is a list of the top 10 human medications most frequently ingested by pets, along with some tips from the veterinarians at Pet Poison Helpline on how to prevent pet poisoning from these common household drugs.

  1. NSAIDs (e.g., Advil®, Aleve® and Motrin®)
    Topping our Top 10 list are common household medications called non-steroidal anti-inflammatories (NSAIDs), which include common names such as ibuprofen (e.g., Advil and some types of Motrin) and naproxen (Aleve). While these medications are safe for people, even one or two pills can cause serious harm to a pet. Dogs, cats, birds and other small mammals (ferrets, gerbils and hamsters) may develop serious stomach and intestinal ulcers as well as kidney failure.

  2. Acetaminophen (e.g., Tylenol®)
    When it comes to pain medications, acetaminophen (e.g., Tylenol) is certainly popular. Even though this drug is very safe for humans, even children, this is not true for pets — especially cats. One regular strength tablet of acetaminophen may cause damage to a cat’s red blood cells, limiting their ability to carry oxygen. In dogs, acetaminophen leads to liver failure and, in large doses, red blood cell damage.

  3. Antidepressants (e.g., Effexor®, Cymbalta®, Prozac®, Lexapro®)
    While these antidepressant drugs are occasionally used in pets, overdoses can lead to serious neurological problems such as sedation, incoordination, tremors and seizures. Some antidepressants also have a stimulant effect leading to a dangerously elevated heart rate, blood pressure and body temperature. Pets, especially cats, seem to enjoy the taste of Effexor and often eat the entire pill. Unfortunately, just one pill can cause serious poisoning.

  4. ADD/ADHD medications (e.g., Concerta®, Adderall®, Ritalin®)
    Medications used to treat Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder contain potent stimulants such as amphetamines and methylphenidate. Even minimal ingestions of these medications by pets can cause life-threatening tremors, seizures, elevated body temperatures and heart problems.

  5. Benzodiazepines and sleep aids (e.g., Xanax®, Klonopin®, Ambien®, Lunesta®)
    These medications are designed to reduce anxiety and help people sleep better. However, in pets, they may have the opposite effect. About half of the dogs who ingest sleep aids become agitated instead of sedate. In addition, these drugs may cause severe lethargy, incoordination (including walking “drunk”), and slowed breathing in pets. In cats, some forms of benzodiazepines can cause liver failure when ingested.

  6. Birth control (e.g., estrogen, estradiol, progesterone)
    Birth control pills often come in packages that dogs find irresistible. Thankfully, small ingestions of these medications typically do not cause trouble. However, large ingestions of estrogen and estradiol can cause bone marrow suppression, particularly in birds. Additionally, female pets that are intact (not spayed), are at an increased risk of side effects from estrogen poisoning.

  7. ACE Inhibitors (e.g., Zestril®, Altace®)
    Angiotensin-converting enzyme (or “ACE”) inhibitors are commonly used to treat high blood pressure in people and, occasionally, pets. While this category of medication is generally quite safe, large overdoses can cause low blood pressure (hypotension), dizziness, weakness, and potentially kidney injury. Pets ingesting small amounts of this medication can potentially be monitored at home, unless they have kidney failure or heart disease. All heart medications should be kept out of reach of pets.

  8. Beta-blockers (e.g., Tenormin®, Toprol®, Coreg®)
    Beta-blockers are also used to treat high blood pressure but, unlike ACE-inhibitors, small ingestions of these drugs may cause serious poisoning in pets. Overdoses can cause life-threatening decreases in blood pressure and a very slow heart rate.

  9. Thyroid hormones (e.g., Armour desiccated thyroid, Synthroid®)
    Pets — especially dogs — get underactive thyroids too. Interestingly, the dose of thyroid hormone needed to treat dogs is much higher than a person’s dose. Therefore, if dogs accidentally get into thyroid hormones at home, it rarely results in problems. However, large acute overdoses in cats and dogs can cause nervousness, panting, a rapid heart rate, aggression and muscle tremors.

  10. Cholesterol-lowering agents (e.g., Lipitor®, Zocor®, Crestor®)
    These popular medications, often called “statins,” are commonly used in the United States. While pets do not typically get high cholesterol, they may still get into the pill bottle. Thankfully, most “statin” ingestions only cause mild vomiting or diarrhea. Serious side effects from these drugs come with long-term use, not one-time ingestions.

Veterinarians: Learn more about treating pet poison victims

Pet Poison Helpline has many critical resources on pet poisonings, some of which we've worked with Wedgewood Pharmacy to compile for you in one eBook. Download the eBook from the Resources for Veterinarians section of WedgewoodPetRx. Additionally, you can attend webinars for CE credit. Register for the next online presentation at PetPoisonHelpline.com. Pet Poison Helpline will be guest blogging here for a few weeks to share with you this important information on treating pet poisonings.


Ahna Brutlag, DVM, MS (Toxicology)
Associate Director of Veterinary Services
Pet Poison Helpline

About Pet Poison Helpline:
Pet Poison Helpline, a division of SafetyCall International, is an animal poison control service based out of Minneapolis available 24 hours, seven days a week for pet owners and veterinary professionals who require assistance treating a potentially poisoned pet. As the most cost-effective option for animal poison control care, Pet Poison Helpline’s fee of $35 per incident includes unlimited follow-up consultations. Pet Poison Helpline is available in North America by calling 800-213-6680. Additional information can be found online at PetPoisonHelpline.com.

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Ahna Brutlag, DVM, MS (Toxicology) 10/11/2011 9:24:00 AM

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